Cortisol

Cortisol is a steroid hormone that helps regulate metabolism, immune activity, blood pressure, and the body’s response to stress.

Cortisol is produced by the adrenal glands under the control of the hypothalamic-pituitary-adrenal (HPA) axis. It helps the body make energy available during periods of increased demand and influences many processes throughout the body.

Cortisol is not simply a “stress hormone.” It is normally present in the body and follows a daily rhythm, typically reaching higher levels in the morning and gradually declining during the day.

QUICK FACT

Cortisol is essential for normal body function. The problem is not having cortisol, but having abnormal levels or patterns of cortisol production.

COMMONLY CONFUSED WITH

  • Adrenaline: Adrenaline produces rapid changes that help prepare the body for immediate action, while cortisol generally has broader and longer-lasting effects.
  • Cortisone: a closely related steroid that has different biological activity

SEE ALSO

Clinical & Educational Context

Discussed in Health Articles & Guides

Explore how "Cortisol" is covered across our evidence-based editorial guides:

2 Articles
The Hard Parts of Medicine

Polypharmacy: What Really Happens When You Take Multiple Medicines

Depending on the dose and duration, gradual reduction may be necessary to allow the body's own cortisol production to recover and to reduce the...
Unstraight Lines

Blame the Hormone

Present but unseen, Felt but untouchable Yet, They blame the hormone Blame cortisol for the sharp reply.