Dose

The amount of a substance or other agent received by or reaching an organism, usually considered in relation to body weight, time, or another relevant measure.

Dose is an important concept in toxicology because biological effects can depend on how much of a substance reaches the body. Scientists may express dose in units such as milligrams per kilogram of body weight per day.

The relationship between dose and harm is not always simple. Different substances can have different dose-response relationships, and factors such as route of exposure, duration, age, and individual susceptibility can influence effects.

COMMONLY CONFUSED WITH

  • Exposure: describes contact with or intake of a substance; dose concerns the amount received or reaching the body.
  • Hazard: describes the potential to cause harm rather than the amount received.

SEE ALSO

Clinical & Educational Context

Discussed in Health Articles & Guides

Explore how "Dose" is covered across our evidence-based editorial guides:

6 Articles
Unstraight Lines

Kill Me a Little, Kill It More

And between its action and my survival lies the fragile mathematics of dose, time, and the differences between what we are and what threatens us.
Health in the Wild

Food Packaging: Unexpected Food Safety Risks you need to know

The presence of PFAS in a package does not by itself establish that a particular food contains a harmful dose.
The Hard Parts of Medicine

Do You Need Supplements? What Medical Research Says

It is which supplement, for whom, for what purpose, at what dose, and with what evidence of benefit?
The Hard Parts of Medicine

Polypharmacy: What Really Happens When You Take Multiple Medicines

Risk depends on the medicines involved, their doses, the person's health, how the medicines interact, and whether the regimen is being monitored appropriately.
Cases & Narratives

His Last Malaria: A Case of Suspected Fake Medicines

The First Few Days Matter Malaria treatment is not necessarily a matter of taking one dose and expecting every symptom to disappear immediately.
Unstraight Lines

40 Pills a Day

Doses too small to feel important.