Depression

A mental health condition characterized by persistent low mood or loss of interest or pleasure, together with other emotional, cognitive, physical, or behavioral changes that affect daily functioning.

Depression can involve changes in sleep, appetite, energy, concentration, movement, self-esteem, and thoughts about oneself or the future. It can vary in severity and may occur as a single episode or recur over time.

Depression is more than a temporary period of sadness. Its causes are complex and can involve biological, psychological, social, and environmental factors.

QUICK FACT

A person with depression does not necessarily appear sad; some people mainly experience fatigue, loss of interest, irritability, or difficulty concentrating.

COMMONLY CONFUSED WITH

Sadness: a normal emotional response that is usually temporary and does not necessarily involve the broader pattern of symptoms or functional impairment seen in depression.

SEE ALSO

Clinical & Educational Context

Discussed in Health Articles & Guides

Explore how "Depression" is covered across our evidence-based editorial guides:

2 Articles
The Hard Parts of Medicine

Do You Need Supplements? What Medical Research Says

Fatigue, for instance, may be associated with iron deficiency, but it can also result from sleep problems, thyroid disease, infections, depression, and many other...
The Hard Parts of Medicine

Polypharmacy: What Really Happens When You Take Multiple Medicines

Opioids can also cause respiratory depression, in which breathing becomes dangerously slow or inadequate.